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 ASER fills the gap of the sex reversal database by integrating diverse information at different levels for the 18 species with sex reversal phenomena, including curated Sex Reversal-associated Genes (SRGs), RNA-seq data, image data, and conservation data. Particularly, ASER provides comprehensive information for SRGs including their regulators, targets, homologous genes, expression dynamics across different conditions, and spatial distribution in different stages. We expect that the resources in ASER will promote further studies to decode the molecular mechanisms of sex reversal. In the future, we will continuously update ASER database as new sex reversal species and genes become available.

In ASER, user can:

• Browse or download genome and literature in sex reversal species.
• Browse or search orthologs of SRGs across genomes.
• Browse or search ISH or FISH information and published evidence of SRGs.
• Browse or search expression, regulatory network, spatial distribution of SRGs, significance of SRGs in certain development stage of sex reversal or gonadogenesis.
• Browse or search high throughput datasets during typical development stage of sex reversal or gonadogenesis.
• Download the SRG analysis results and information from 18 species.

Citation: Li, Y., Chen, Z., Liu, H., Li, Q., Lin, X., Ji, S., Li, R., Li, S., Fan, W., Zhao, H., Zhu, Z., Hu, W., Zhou, Y., & Luo, D. (2021). ASER: Animal Sex Reversal Database. Genomics, proteomics & bioinformatics, S1672-0229(21)00244-8.

How to use ASER?

Including homology alignment, RNA-seq data processing, and transcriptome assembly.

Q: What is SRG?

A: SRGs, sex reversal associated genes, which were validated to be functional in sex reversal in different species.

Q: What kind of information can I find in ASER?

A: ASER is unique in identifying SRGs driving sex reversal, and their regulatory network, expression dynamics, conservation data and spatial distribution from literature and available data.

Q: What species are covered in ASER?

A: ASER screens 18 important and typical species with sex reversal phenomenon from teleostei to mammalia, and summarized the major inducements of sex reversal or common approaches used to manipulate sex in these species.

Q: Where does ASER's data come from?

A: SRGs information and their regulatory networks were curated from PubMed literature. All genome sequences and species information used in this database were downloaded from NCBI public databases. All raw sequencing data were downloaded from the Sequence Read Archive (SRA) of NCBI. The sets of RNA-seq data are organized by species, gonad developmental stages, and temperature. In addition, we retrieved the images related to sex reversal from OPENi (https://openi.nlm.nih.gov/) and ZFIN database (https://zfin.org).

All results from ASER come from third-party tools non-experimentally and must be considered with care. All information on the ASER is provided "AS-IS", without any express or implied warranty.

ASER is developed by Luo lab in Institute of Hydrobiology, Chinese Academy of Science.

Charge — ASER can be used for any non-commercial use free of charge. Academic cooperation sponsored by industry partners is not regarded as academic research, but for commercial purposes. Industrial use of ASER at any stage of research, development and/or commercial development is considered a commercial purpose. If you are a business and want to use ASER, or if you want to use ASER for commercial purposes, please contact us first.

Attribution — When you publish, patent or distribute results that were fully or partially based on models obtained from ASER, please cite the corresponding papers.

No additional restrictions — you may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.

ASER will not save and use any user information (including cookies). The data transmission between the user and ASER uses an unencrypted clear text protocol. Do not use ASER on any data that must be kept confidential for legal or IP reasons. All services are provided "AS-IS" without any express or implied warranty.

There is no limit to the interactive use of ASER by individual users. Activities that may affect the stable operation of the service, such as automatic query and download, automatic submission, etc. are forbidden and may result in blocking your access.

If you are interested in our project or have any suggestions, please contact Luo Lab (luodaji@ihb.ac.cn or chenzonggui@ihb.ac.cn).